College of Veterinary Medicine

People in WSU Veterinary Medicine

Cleverson D Souza


Souza, CleversonCleverson D Souza, DVM, MSc, Ph.D., DACVP 
Assistant Professor of Clinical Pathology
Veterinary Clinical Sciences, College of Veterinary Medicine
Office: +1 (509).335.0726 - 2031 ADBF
Lab: +1 (509).335.1417 
Pullman, WA, 99164-6610
souza@vetmed.wsu.edu

Dr. Souza is a citizen of Brazil and received his Doctor of Veterinary Medicine (DVM) in 1998 from the Universidade Federal do Parana, PR, Brazil. Dr Souza has been trained in research and pathology at multiple Universities. After receiving his DVM he completed a 2 year residency program in Sao Paulo/Br followed by a thesis Master Science degree in Clinical Pathology at Universidade Federal de Santa Maria/Rio Grande do Sul/Br. He worked as a veterinary clinical pathologist at Universidade de Passo Fundo/RS for 1 year before accepting a PhD position and joining Dr Douglas J Weiss (DVM, PhD, DACVP) lab at the University of Minnesota/USA. The research involved unraveling key cell signaling pathways important for the ability of Mycobacterium paratuberculosis to survive within macrophages. This training was followed by a residency in veterinary clinical pathology at University of Minnesota/USA. He then successfully completed his specialty board certification through the American College of Veterinary Pathologists (ACVP). From 2009 to 2012, Dr Souza worked at Universidade de FortalezaUniChristus and Universidade Federal do Ceara, all in Brazil, where he was involved with the instruction of general pathology to MDs and DDs students. Dr Souza is currently a tenure-track faculty at the Washington State University where he work as a clinical pathologist (service, teaching and research) at the Veterinary Clinical Science Department.

Education

  • Ph.D - University of Minnesota, St Paul, MN. Project: Host-pathogen interaction in Mycobacterium avium subsp. paratuberculosis infection: Role of the mitogen activated protein kinases in regulating antimicrobial responses of mononuclear phagocytes
  • Residency in Veterinary Clinical Pathology - University of Minnesota, MN, USA
  • MSc – Universidade Federal de Santa Maria, RS, Brazil. Project: Evaluation of the neutrophilic oxidative burst in Saanen goats naturally infected by Haemonchus contortus
  • Residency in Veterinary Clinical Pathology - Universidade Estadual Paulista/UNESP, SP, Brazil
  • DVM – Universidade Federal do Parana, PR, Brazil

Research Interests

Dr. Souza’s lab investigate the cell signaling pathways modulated upon Mycobacterium avium subsp paratuberculosis (MAP) early interaction with professional phagocytes. The lab also work rationally applying these knowledge to generate an effective particle vaccine. Clinical research involves an exciting project where nanomaterials and dendritic cells are used to boost immune responses against malignant tumors in dogs (i.e., personalized immunotherapy). Teaching interest include application of modern instructional methodologies to teach Veterinary Clinical Pathology

Professional positions

  • Assistant Professor of Veterinary Clinical Pathology, Department of Veterinary Clinical Sciences, Washington State University, College of Veterinary Medicine, WA, USA, Jan 2013 to present .http://www.wsu.edu/
  • Assistant Professor of Pathology, Universidade de Fortaleza, School of Medicine, CE, Brazil, Jan 2009 to Dec 2012. http://www.unifor.br/
  • Pathology Lecturer, Faculdade UniChristus, CE, Brazil, Sep 2009 to Dec 2012. http://unichristus.edu.br/
  • Pathology Lecturer, Department of Pathology and Legal Medicine, Universidade Federal do Ceara, School of Medicine and Dentistry, CE, Brazil, Jan 2010 to Dec 2012. http://www.medicina.ufc.br/
  • Veterinary Clinical Pathologist, Laforvet, Jan 2009 to Dec 2012. http://www.laforvet.com.br/
  • Assistant Professor of Veterinary Clinical Pathology, Faculty of Veterinary Medicine, Universidade de Passo Fundo, RS, Brazil, Jun 2002 to Sept 2003. http://www.upf.br

Teaching Awards

  • 2016 Jerry Newberry Teaching Scholar

Selected Publications

D. Guldner, P. Ziaei, Maria C Cardieri, Meaghan Eren, M. Grant Norton, SOUZA. CD (corresponding author). In vitro evaluation of the biological responses of canine macrophages challenged with PLGA nanoparticles containing Monophosphoryl Lipid A. PLoS One, Nov 11;11(11), 2016.

SOUZA CD. Blocking the mitogen activated protein kinase-p38 pathway is associate with increase expression of Nitric Oxide Synthase and higher production of Nitric Oxide by bovine macrophages infected with Mycobacterium avium subsp paratuberculosis. Veterinary Immunology and immunopathology, doi:10.1016/j.vetimm.2015.01.007, 2015.

Bannantine, J., Stable, J., Laws, E., Cardieri, MC., SOUZA CD (corresponding author). Mycobacterium avium subspecies paratuberculosis recombinant proteins modulate antimycobacterial functions of bovine macrophages, PLoS ONE 10(6): e0128966. doi:10.1371, 2015.

SOUZA C, et al., Mannosylated Lipoarabinomannans from Mycobacterium Avium Subsp. Paratuberculosis Alters the Inflammatory Response by Bovine Macrophages and Suppresses Killing of Mycobacterium avium subsp. avium Organisms. PLoS ONE 8(9):e75924. doi:10.1371,  2013

Weiss, DJ and SOUZA, CD. Modulation of Macrophage Function by Mycobacterium avium subsp. paratuberculosis: A Review. Veterinary Pathology, 45:829-841, 2008

SOUZA, CD; Weiss, DJ, Evanson, O. Cell membrane receptors involved in suppression of monocyte anti-microbial activity against Mycobacterium paratuberculosis. Microbial Pathogenesis, Mar; 44(3):215-23, 2008

Weiss, DJ; SOUZA, CD; Evanson; O. Sanders; M, Rutherford M. Bovine monocyte TLR2 receptors differentially regulate the intracellular fate of Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium. Journal of Leukocyte Biology, Jan;83(1):48-55, 2008

Weiss, DJ; SOUZA, CD; Evanson, O. Nuclear factor-kB regulates cytokine expression and apoptosis in bovine monocytes infected with Mycobacterium avium subsp. paratuberculosis. American Journal of Veterinary Research, Jun;69(6):804-10, 2008

SOUZA, CD; Weiss, DJ, Evanson, O. Role of the mitogen-activated protein kinase pathway in the differential response of bovine monocytes to Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium, Microbes and Infection, Nov-Dec;9(14-15):1545-52, 2007

SOUZA, CD; Weiss, DJ, Evanson, O. Role of the MAPK-ERK pathway regulating cytokine expression by Mycobacterium avium subsp. paratuberculosis-infected bovine monocytes. American Journal of Veterinary Research, Jun; 68(6):625-30, 2007

SOUZA, CD; et al. Cell Membrane Receptors in Bovine Mononuclear Phagocytes Involved in Phagocytosis of Mycobacterium avium subsp. paratuberculosis. American Journal of Veterinary Research, Sept (68): 975-980, 2007

SOUZA, CD; Weiss, DJ, Evanson, O. Mitogen Activated Protein Kinase-p38 pathway is an important component of the anti-inflammatory response in Mycobacterium avium-infected bovine monocytes. Microbial Pathogenesis, v. 41(2-3):59-66, 2006

Weiss, DJ, SOUZA, CD, Evanson, O. Mucosal immune response in cattle with, subclinical Johne's disease. Veterinary Pathology, (43): 127-135, 2006

SOUZA, CD; Weiss, DJ, Evanson, O. Jun n-terminal kinase (MAPK-JNK/SAPK) regulates cytokine expression in Mycobacterium avium subsp. paratuberculosis-infected bovine monocytes. American Journal of Veterinary Research, Vol. 67, No. 10: 1760-1765, 2006

SOUZA, CD; Lopes, STA, Batina, P, et al. Parasitic stress in Saanen Goats: Evaluation of the CBC and neutrophilic oxidative burst. Revista Veterinaria Noticias, v. 12, n. 2, p. 35-40,  2006.

Weiss, DJ, Evanson, O, SOUZA, CD. Expression of interleukin-10 and suppressor of cytokine signaling-3 associated with susceptibility to Jonhe's disease. American Journal of Veterinary Research, Jul;66 (7):1114-20, 2005

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